RECORDED BioBasics 201: Targeted Therapeutics Explained for the Non-Scientist

Explore the Human Immune System in this introductory Immunology course. Learn about immune system tissues, non-specific and specific immunity, the roles of key immune cells, and the importance of immune signaling through cytokines, with real-world applications such as managing cytokine storms.

Explore how our body fights disease through Immunology. Uncover the mechanisms behind non-specific and specific immune responses, learn about B-cells, antibodies, the complement response, T-cells, and the regulation of the immune system. Discover real-world applications, including insights into inflammation, monoclonal antibodies, and tumor suppression of T-cells.

Discover the world of Targeted Biologics: Vaccines. Learn about immunological memory, the mechanisms behind vaccines, and various vaccine platforms. Explore the emerging field of DNA and RNA vaccines, with a spotlight on the industry application of a universal flu vaccine.

Get to know the intricate world of cancer, delve into the mechanisms of growth factor signaling, and discover the industry application of Gleevec. Understand the complexities of the immunosuppressive tumor microenvironment and the exciting developments in cancer immunotherapy.

Uncover the world of therapeutic antibodies, their mechanisms of action, and the difference between polyclonal and monoclonal antibodies. Dive into the innovative field of antibody-drug conjugates and biospecific antibodies. Learn about their industry applications, including the role of PD-1, PD-L1, CTLA-4, and next-generation checkpoint inhibitors.

Uncover the world of therapeutic antibodies, their mechanisms of action, and the difference between polyclonal and monoclonal antibodies. Dive into the innovative field of antibody-drug conjugates and biospecific antibodies. Learn about their industry applications, including the role of PD-1, PD-L1, CTLA-4, and next-generation checkpoint inhibitors.

Examine the therapeutic potential of RNA-based therapies, including antisense and siRNA technologies, and how these approaches are being applied in clinical settings. Key industry applications such as Kynamro, an antisense therapy, and Spinraza, which utilizes exon inclusion and exon skipping, will be discussed in depth. 

Explore DNA delivery methods, particularly through viral vectors, and the various viral vector platforms, including the characteristics of AAV and lentivirus in gene therapy composition. Key industry applications, such as Luxturna and Zolgensma, will be discussed, highlighting their real-world impact. Topics will also include AAV neutralizing antibodies, gene therapy biomarkers, and the durability of therapeutic effects. Additionally, the week will cover RMAT designation and the associated risks and challenges in gene therapy development.

This week explores the various medical and therapeutic applications of CRISPR technology. Covering how CRISPR is being used to target genetic disorders, cancer, and infectious diseases, providing an overview of current research and clinical trials. The discussion also includes emerging trends in using CRISPR for rare diseases and potential future applications in personalized medicine.

Dive into different types of immunotherapies, including therapeutic antibodies, oncolytic virus therapy, vaccines, and CAR-T cell therapy. Learn how each approach activates the immune system to combat diseases, with a special focus on their revolutionary impact in cancer treatment. Examine the latest advancements and what the future holds for these groundbreaking therapies.

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